Cris Cerebrale – CNS Diseases Case Study
Why is it drugs targeting the ischaemic cascade* have been unsuccessful in trials?
You should cite a specific example of a target and drug that have been trialled in humans, together with the outcome in animals and humans (150-200words) followed by a general discussion of theproblems that have been encountered when targeting theischaemic cascade therapeutically and translating outcomes inanimals to humans (250-350 words).
Make sure to include a diagram of the ischemic cascade and where/how drug interacts with the pathway.
* – your drug must act on a target within the ischaemic cascade and be neuroprotective this means NO thrombolytics
